This issue of Pediatric Clinics, guest edited by Drs. Mark Swanson and Adrian Sandler, offers exciting new insights on Spina Bifida. New transition guidelines for youth with spina bifida have been developed by an interdisciplinary team of experts from around the country. These guidelines are covered in this issue, along with articles on developmental pediatrics' and rehabilitation medicine's approaches to Spina Bifida, approaches to transition in other chronic illnesses and conditions, continence across the lifespan, and the challenge of incorporating cultural perspectives into services and supports.