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SCN2A-Related Disorders

SCN2A-Related Disorders

296 kr

296 kr


Denne artikkelen vil bli

utgitt 2. jan. 2025


Få artikkelen når den slippes, eller kort tid etter


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Åpent kjøp til og med 7/1-25


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Adlibris


Produktbeskrivelse

SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.

Artikkel nr.

13c150e5-47d3-5233-a2c4-9ca9a8b96fa9

SCN2A-Related Disorders

296 kr

296 kr


Denne artikkelen vil bli

utgitt 2. jan. 2025


Få artikkelen når den slippes, eller kort tid etter


Sikker betaling

Åpent kjøp til og med 7/1-25


Selges og leveres av

Adlibris