This new issue of Clinics in Geriatric Medicine, guest edited by Edgar Lerma, examines critical aspects of renal disease from anatomic and physiologic changes in the aging kidney, to ethical issues in elderly with patients with renal disease. Authors from the United States and abroad cover topics in this issue such as: drug dosing and the elderly kidney, diabetic nephropathy, renal replacement therapy, glomerular diseases in the elderly, urinary tract infections, obstructive uropathy, and urinary incontinence.