This portable and practical handbook, first published in 2006, provides a concise guide to the essentials of pediatric HIV care in a form suitable for doctors in the busy hospital setting. During recent years, many agents for the treatment and prophylaxis of HIV infection and the opportunistic infections that accompany HIV infection have been developed, and many new ways of monitoring HIV infection in children have been produced. These therapies and approaches to management are complicated, but the long-term health of HIV-infected children depends on their correct application. This handbook presents the core information and guidelines necessary for effective management of infected children. Two other important themes are ways to minimise mother-to-infant transmission, and the challenges of looking after these children in resource-poor countries.