In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Scott Leibowitz, Serena Chang, and Natalia Ramos bring their considerable expertise to the topic of Transgender and Gender Diverse Children and Adolescents. Top experts in the field cover key topics such as complex psychiatric histories and gender diverse/transgender youth; neurodiversity and transgender/gender diverse youth: the co-occurrence; individual affirming care: psychological and social approaches to trans and gender diverse youth; psychosocial family treatments and navigating family dynamics; and more. Contains 16 relevant, practice-oriented topics including gender in youth; beyond sex and gender: dimensions across child and adolescent development; gender affirming medical treatments; perspectives: being a trans psychiatrist/provider; and more. Provides in-depth clinical reviews on transgender and gender diverse children and adolescents, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.