This issue of Nursing Clinics includes the following topics: Nursing interventions for smoking cessation; tobacco cessation clinics; Cessation strategies for pregnant and postpartum mothers; Evidence-based cessation strategies and policies for college-age smokers; Evidence-based cessation strategies for rural communities; Gender differences and tobacco cessation; Optimizing tobacco cessation outcomes; Community based participatory research and cessation interventions; Use of quit-lines for cessation; Advocacy and smoke-free laws; Hookah use in adolescents and adults; Chewing tobacco; and E-cigarettes.