In this issue of Neuroimaging Clinics, guest editors Drs. Bryan Lanzman and Tarik F. Massoud bring their considerable expertise to the topic of The Subarachnoid Space: Percutaneous Access for Diagnosis and Image-Guided Therapies. In this first-of-its-kind issue, top experts the field discuss a wide range of topics related to the subarachnoid space, including imaging anatomy, guided lumbar punctures, puncture complications, myelography, cisternography, and much more. Contains 12 relevant, practice-oriented topics including imaging anatomy of cerebrospinal fluid spaces; standard fluoroscopic and CT-guided lumbar punctures; fluoroscopic, CT, and MR myelography; CT and MR cisternography; lumbar puncture, myelography, and cisternography in children; and more. Provides in-depth clinical reviews on the subarachnoid space, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.