In this issue of Clinics in Plastic Surgery, guest editors Drs. Kevin C. Chung and Brian Starr bring their considerable expertise to the topic of Hand and Upper Extremity Surgery. Top experts in the field discuss key topics such as principles for achieving predictable outcomes in flexor tendon repair; nerve vs. tendon transfers in the management of isolated upper extremity peripheral nerve injuries; free functional muscle transfer; current and future directions for upper extremity amputations: TMR vs. RPNI; and more. Contains 13 relevant, practice-oriented topics including optimizing outcomes in revision peripheral nerve surgery; the mangled upper extremity: algorithm for salvage/my workhorse flaps; bone grafts and flaps in the management of complex upper extremity defects; optimizing outcomes in the management of the burned hand; preserving and reconstructing the traumatized thumb; and more. Provides in-depth clinical reviews on hand and upper extremity surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.