In this issue of Urologic Clinics of North America, guest editor Dr. Andrew J. Hung brings his considerable expertise to the topic of Artificial Intelligence in Urology. Alongside technological advancements in artificial intelligence (AI), applications of AI in urology have grown tremendously over the last few years. This special issue highlights areas of particular interest, such as radiomics, pathomics, genomics, and surgery. Top experts in the field cover the current status and also preview future applications, aimed at improved patient outcomes. Contains 13 relevant, practice-oriented topics including radiomics, pathomics, and surgical AI; genomics and AI: prostate cancer and renal cell carcinoma; pediatric urology and AI; bladder cancer and AI; AI in urology: big data sets; and more. Provides in-depth clinical reviews on artificial intelligence in urology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.