Advances in Clinical Chemistry, Volume 124 provides the fundamentals of physiologic and pathophysiologic biochemistry in general and clinical chemistry. Complex molecular pathways are elucidated using historical, current, and emerging technologies such as biosensor design and development. Identification of novel biomarkers and accurate and precise analysis are key to cutting-edge patient care, diagnostics, and treatment. This series strategically focuses on new tools for the detection of novel biomarkers, especially in light of an aging worldwide population faced with increased prevalence of chronic disease, many of which lack early diagnostic tools that are so essential to patient care and socioeconomic outcome.