This issue of Interventional Cardiology Clinics, guest edited by Dr. Susheel Kodali, will cover several key topics of importance surrounding Transcatheter Aortic Valve Replacement. The series is overseen by the Editor-in-Chief, Dr. Matthew Price of Scripps Translational Science Center. Subjects discussed in the issue include: Embolic protection during TAVR; Impact of Atrial Fibrillation on Outcomes Following TAVR; When to Intervene; Innovations in Transcatheter Valve Technology; Paravalvular Regurgitation; Challenges and Pitfalls of Bicuspid Valves; Tips and Tricks for Valve in Valve, and When to Choose Surgery in the Era of TAVR, among others.