Progress in the applications of biotechnology depends on a wide base of basic as well as applied sciences. The output of biotechnology has already proved itself in many different fields, from health to biomining, and from agriculture to enzyme "breeding". The objectives of the Biotechnology Annual Review series is to provide readers with the needed in-depth knowledge by reviewing specific topics in each volume. In this way, it is easier for scientists to keep in touch with progress and applications in biotechnology. Up-to-date topics are reviewed that are related to regulatory affairs, social impact, biodiversity and patent issues, as well as production and technology.