In this issue of Infectious Disease Clinics of North America, guest editor Dr. Robert P. Smith brings his considerable expertise to the topic of Lyme Disease and the Expanding Spectrum of Associated Tick-Borne Illness. With a primary focus on Lyme disease and its complications, the thorough reviews in this issue will also discuss the epidemiology, clinical presentations, diagnosis, treatment and outcomes of other infections transmitted by the black-legged tick in North America. The complexity of the public narrative of these diseases will also be addressed with an eye toward providing the clinician with a context for response. Contains 14 practice-oriented topics including early Lyme disease: erythema migrans and Its mimics; Lyme arthritis; neurologic Lyme disease: four common fallacies and three diagnostic requirements; persistent symptoms in patients with treated Lyme disease; ID specialists approach to consultation in patients referred for refractory illness attributed to tick-borne disease; and more.  Provides in-depth clinical reviews on Lyme disease and the expanding spectrum of associated tick-borne illness, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.